Copper(II) Chelates with Glycine and Histidine

Metal chelates of glycine and glycine peptides.

Since the advancement by Smith et al. (l-4) of the theory that metal ions are chelated simultaneously to enzyme protein and substrate in various polypeptidases, the nature of metal binding to peptides and proteins has become an important as well as an interesting problem. The chelate structures proposed by Smith (3), and later somewhat revised (5, 6), indicate that the metal is bound, at least ...

Glutamate-glycine and histidine-glycine co-oligopeptides: batch co-oligomerization versus pulsed addition of N-carboxyanhydrides.

Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein.

The Ni(II) complex of the tripeptide NH2-glycine-glycine-histidine-COOH (GGH) mediates efficient protein-protein cross-linking in the presence of oxidants such as oxone and monoperoxyphthalic acid (MMPP). Here we demonstrate that GGH fused to the amino terminus of a protein can still support cross-linking. The tripeptide was expressed at the amino terminus of ecotin, a dimeric macromolecular se...

Certain aspects of glycine and histidine metabolism in patients with sprue.

IT HAS BEEN BELIEVED that tropical sprue is caused by a primary folic acid deficiency,’2 although direct evidence in support of this concept is inadequate. While the administration of folic acid to patients with sprue in relapse will lead to clinical improvement, the remissions are often incomplete and malabsorption persists. Sprue may be conspicuously absent in the presence of gross vitamin an...

the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group

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